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Cancer

Medulloblastoma

Medulloblastoma is a primitive neuroectodermal tumor (PNET) found in the cerebella of children. This tumour accounts for approximately 7-8% of all intracranial tumours and 30% of paediatric brain tumours. The incidence of medulloblastoma is 1.5-2 cases per 100,000 population, more common in males than females (1.5:1). Although cancer is rare in children, brain tumours are the most common type of childhood cancer other than leukaemia and lymphoma.

The signs of childhood medulloblastoma vary and often depend on the child’s age and where the tumour is located.

These symptoms may be caused by a medulloblastoma or other conditions. A doctor should be consulted if any of the following problems occur:

  • Loss of balance, difficulty walking, worsening handwriting, or slow speech.
  • Morning headache or headache that goes away after vomiting.
  • Nausea and vomiting.
  • Unusual sleepiness or change in energy level.
  • Change in personality or behaviour.
  • Unexplained weight loss or weight gain.


The tumour has the propensity of spreading throughout the CNS.

The treatment is a combination of surgery, radiotherapy and chemotherapy.

References

1. Bailey P, Cushing H. Medulloblastoma cerebelli: a common type of midcerebelar glioma of childhood. Arch Neurol Psych 1925;14:192–224.

2. Hart MN, Earle KM. Primitive neuroectodermal tumors of the brain in children. Cancer 1973;32:890-897.

3. Rorke LB. The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 1983;42:1-15.

4. Nelson AA. Metastases of intracranial tumor. Am J Cancer 1936;28:1–12.

5. DiRocco C, Iannelli A, Tancredi A. Patterns of failure in surgical therapy of medulloblastomas. J Neurosurg Sci 1995;39:1–6.

6. Farwell JR, Flannery JT. Adult ocurrence of medulloblastoma. Acta Neurochir 1987;86:1–5.

7. Berger MS, Baumeister B, Geyer, JR, Milstein J, Knev PM, LeRoux PD. The risks of metastases from shunting in children with primary central nervous system tumors. J Neurosurg 1991;74 :872–877.

8. Chamberlain MC, Silver P, Edwards MS, Levin VA. Treatment of extraneural metastatic medulloblastoma with a combination of cyclophosphamide, adriamycin and vincristine. Neurosurgery 1988;23:476–479.

9. Rochkind S, Blatt I, Sadeh M, Goldhammer Y. Extracranial metastases of medulloblastoma in adults: literature review. J Neurol Neurosurg Psychiatry 1991;54:80–86.

10. American Society of Clinical Oncology (ASCO) http://www.plwc.org
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